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两性霉素 B 可降低伏立康唑血清水平:一病例报告及文献综述
Received 16 May 2022
Accepted for publication 5 September 2022
Published 12 September 2022 Volume 2022:15 Pages 5397—5400
DOI https://doi.org/10.2147/IDR.S374853
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Suresh Antony
Background: Combination therapy with amphotericin B (AmB) and Voriconazole are sometimes used due to reducing AmB-related adverse reactions and improving outcomes. However, there was no report whether AmB would affect the serum level of Voriconazole.
Case Presentation: A patient was in presumption of invasive fungal infection. Voriconazole and amphotericin B was combined for administration. The results showed that serum levels of Voriconazole were dramatically reduced when combined AmB, whereas went up when receiving Voriconazole alone.
Conclusion: AmB might decrease the level of Voriconazole. Such a combination of AmB and Voriconazole cannot be considered appropriate until more data are available.
Keywords: amphotericin B, voriconazole, fungal infection, drug interaction