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基于天然产物的纳米制剂:一种针对 CSC 进行癌症治疗的新方法
Authors Liao W, Li Y, Wang J, Zhao M, Chen N, Zheng Q, Wan L, Mou Y , Tang J, Wang Z
Received 7 July 2022
Accepted for publication 25 August 2022
Published 14 September 2022 Volume 2022:17 Pages 4163—4193
DOI https://doi.org/10.2147/IJN.S380697
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Yan Shen
Abstract: Cancer stem cells (CSCs) lead to the occurrence and progression of cancer due to their strong tumorigenic, self-renewal, and multidirectional differentiation abilities. Existing cancer treatment methods cannot effectively kill or inhibit CSCs but instead enrich them and produce stronger proliferation, invasion, and metastasis capabilities, resulting in cancer recurrence and treatment resistance, which has become a difficult problem in clinical treatment. Therefore, targeting CSCs may be the most promising approach for comprehensive cancer therapy in the future. A variety of natural products (NP) have significant antitumor effects and have been identified to target and inhibit CSCs. However, pharmacokinetic defects and off-target effects have greatly hindered their clinical translation. NP-based nanoformulations (NPNs) have tremendous potential to overcome the disadvantages of NP against CSCs through site-specific delivery and by improving their pharmacokinetic parameters. In this review, we summarize the recent progress of NPNs targeting CSCs in cancer therapy, looking forward to transforming preclinical research results into clinical applications and bringing new prospects for cancer treatment.
Keywords: cancer, cancer stem cells, nanoformulations, natural products, targeted therapy