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碳点在治疗阿尔茨海默病中的应用
Authors Guo F, Li Q, Zhang X, Liu Y, Jiang J, Cheng S, Yu S, Zhang X, Liu F, Li Y, Rose G, Zhang H
Received 13 September 2022
Accepted for publication 29 November 2022
Published 23 December 2022 Volume 2022:17 Pages 6621—6638
DOI https://doi.org/10.2147/IJN.S388030
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Phong A Tran
Abstract: There are currently approximately 50 million victims of Alzheimer’s disease (AD) worldwide. The exact cause of the disease is unknown at this time, but amyloid plaques and neurofibrillary tangles in the brain are hallmarks of the disease. Current drug treatments for AD may slow the progression of the disease and improve the quality of life of patients, but they are often only minimally effective and are not cures. A major obstacle to developing and delivering more effective drug therapies is the presence of the blood-brain barrier (BBB), which prevents many compounds with therapeutic potential from reaching the central nervous system. Nanotechnology may provide a solution to this problem. Among the medical nanomaterials currently being studied, carbon dots (CDs) have attracted widespread attention because of their ability to cross the BBB, non-toxicity, and potential for drug/gene delivery.
Keywords: Alzheimer’s disease, blood-brain barrier, nanoparticles, carbon dots, gene delivery