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下呼吸道纹状棒状杆菌感染的靶向抗生素
Authors Zhang H , Tan X, Zhang Z, Yang X, Wang L, Li M , Shi D, Li Y, Li J, Li Z, Liao X
Received 14 January 2023
Accepted for publication 29 March 2023
Published 4 April 2023 Volume 2023:16 Pages 2019—2028
DOI https://doi.org/10.2147/IDR.S404855
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Suresh Antony
Purpose: To assess the impact of targeted antibiotic therapy on clinical outcomes of patients with lower respiratory tract (LRT) infection with Corynebacterium striatum (C. striatum).
Methods: A new propensity score-inverse probability of treatment weighting (IPTW) cohort study was conducted by using 10-year data. The study included LRT infection patients with respiratory secretions cultured positive for C. striatum simultaneously. The primary outcome was all-cause hospital mortality; the secondary outcomes included hospital stay, ICU stay and ventilation time. The safety outcomes were drug-related serum creatinine (Cr) increase and thrombocytopenia.
Results: A total of 339 patients were included in the cohort, and 84 (24.78%) initiated vancomycin or linezolid therapy. In the new IPTW cohort, targeted antibiotic therapy did not improve all-cause hospital mortality (P =0.632), and the OR (95% CI) was 0.879 (0.519– 1.488). Moreover, targeted antibiotic therapy was not associated with hospital stay (P =0.415), ICU stay (P =0.945) or ventilation time (P =0.885). The side effects of drug-related higher serum Cr (P =0.044) and thrombocytopenic levels (P =0.038) cannot be ignored.
Conclusion: Clinical benefits by vancomycin or linezolid targeted against LRT infection with C. striatum were limited and with drug-related side effects. A prospectively designed study is needed to further confirm the results.
Keywords: Corynebacterium striatum , lower respiratory tract infection, vancomycin, linezolid, all-cause mortality