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中药有效成分调控细胞自噬治疗急性肺损伤的研究进展
Authors Dong JY, Yin HL, Hao H, Liu Y
Received 18 November 2022
Accepted for publication 11 April 2023
Published 17 April 2023 Volume 2023:16 Pages 1671—1691
DOI https://doi.org/10.2147/JIR.S398203
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Monika Sharma
Abstract: Autophagy is a highly conserved process that maintains cell stability in eukaryotes, participates in the turnover of intracellular substances to maintain cell function, helps to resist pathogen invasion, and improves cell tolerance to environmental changes. Autophagy has been observed in many diseases, and the symptoms of these diseases are significantly improved by regulating autophagy. Autophagy is also involved in the development of lung diseases. Studies have shown that autophagy may play a beneficial or harmful role in acute lung injury (ALI), and ALI has been treated with traditional Chinese medicine designed to promote or inhibit autophagy. In this paper, the molecular mechanism and common pathways regulating autophagy and the relationship between autophagy and ALI are introduced, and the active ingredients of traditional Chinese medicine that improve ALI symptoms by regulating autophagy are summarized.
Keywords: autophagy, inflammation, oxidative stress, apoptosis