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实足年龄与血脂异常之间的关联:一项针对中国老年人口的横断面研究
Authors Li Q , Jiang Y, Song A, Li Y, Xu X, Xu R
Received 28 January 2023
Accepted for publication 14 April 2023
Published 20 April 2023 Volume 2023:18 Pages 667—675
DOI https://doi.org/10.2147/CIA.S406237
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Zhi-Ying Wu
Background and Aims: Dyslipidemia is obviously an important risk factor for cardiovascular diseases, which might further lead to disability and death in aged population. We thus performed the current study to evaluate the association between chronological age and dyslipidemia.
Subjects and Methods: A total number of 59,716 Chinese aged population (31,174 men and 28,542 women, average age 67.8y) were included in the current study. Age and sex were abstracted from medical records. Height, body weight, and blood pressure were measured by trained nurses. Serum concentration of total cholesterol (TC) and total triglycerides were performed by enzyme-linked immunosorbent method after at least 8-h fast. Dyslipidemia was defined if total cholesterol≥ 5.7 mmol/L, or total triglycerides≥ 1.7 mmol/L, or self-reported history of dyslipidemia.
Results: The prevalence of dyslipidemia was 50.4% in the current study population. Compared to the youngest age group (60– 64y), the adjusted odds ratio was 0.88 (95% CI: 0.84, 0.92), 0.77 (95% CI: 0.73, 0.81), 0.66 (95% CI: 0.61, 0.70), 0.55 (95% CI: 0.50, 0.59) for the participants who were 65 to 69, 70– 74, 75– 79, and ≥ 80 years old (p trend < 0.001). Excluding participants with low body weight and with overweight and obesity, with high blood pressure and history of hypertension, with high fasting blood glucose and history of diabetes, generated similar results with main analysis.
Conclusion: Chronological age was closely associated with the risk of dyslipidemia in Chinese aged population.
Keywords: age, total cholesterol, TC, total triglycerides, TG, dyslipidemia