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中国 2 型糖尿病患者血清叶酸水平与 HOMA-IR 的相关性
Authors Yang X, Hu R , Wang Z, Hou Y, Song G
Received 13 March 2023
Accepted for publication 2 May 2023
Published 19 May 2023 Volume 2023:16 Pages 1481—1491
DOI https://doi.org/10.2147/DMSO.S409291
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Antonio Brunetti
Background: Adequate intake of folic acid (FA) has been proven essential for metabolism, cellular homeostasis, and antioxidant effects in diabetic patients. Our aim was to evaluate the association between serum folate levels and the risk of insulin resistance in patients with type 2 diabetes mellitus (T2DM) and to provide new ideas and approaches for reducing the risk of T2DM.
Methods: This was a case–control study involving 412 participants (206 with T2DM). Anthropometric parameters, islet function, biochemical parameters and body composition of T2DM group and control group were determined. Correlation analysis and logistic regression were used to evaluate the risk factors associated with the onset of insulin resistance in T2DM.
Results: The folate levels in type 2 diabetic patients with insulin resistance were significantly lower than those in patients without insulin resistance. Logistic regression showed that FA and high-density lipoprotein were independent influencing factors for insulin resistance in diabetic patients (P < 0.05). After adjusting for confounding factors, the degree of insulin resistance in diabetic patients was in a significant inverse relationship with folate levels (P < 0.05). We also found that below the serum FA threshold of 7.09 ng/mL insulin resistance was significantly more elevated.
Conclusion: Our findings suggest that the risk of insulin resistance increases with the decrease in serum FA levels in T2DM patients. Monitoring folate levels in these patients and FA supplementation are warranted preventive measures.
Keywords: folic acid, type 2 diabetes mellitus, insulin resistance, Chinese