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血清型 CC17 B 群链球菌在中国南方两个家庭聚集引起的新生儿迟发性脑膜炎
Received 27 December 2022
Accepted for publication 29 March 2023
Published 31 May 2023 Volume 2023:16 Pages 3417—3424
DOI https://doi.org/10.2147/IDR.S401545
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Suresh Antony
Background: Late-onset meningitis infected by group B Streptococcus (GBS) continues to be a major cause of perinatal mortality, morbidity and long-term neurodevelopmental sequelae despite the implementation of universal screening, but its risk factors are not fully understood.
Case Presentation: We reported a set of dizygotic twins and a pair of compatriot siblings diagnosed with late-onset GBS meningitis aggregating in two Chinese families. All of GBS strains were identified as serotype III CC17 with high homology between the strains within the same family, and the isolates from the compatriots identical to their mother’s carriage. The siblings in the two families presented clinical signs several days after close contact with their index cases having a fever at home, and obtained prompt diagnosis and anti-infective therapy. The two index patients had obvious brain damage before effective treatment and severe sequelae compared to their siblings with complete healing.
Conclusion: The dramatic difference in outcomes between the index cases and their siblings brings attention to prevent and control familial aggregation of neonatal late-onset GBS infection which never reported in China.
Keywords: group B Streptococcus , neonate, meningitis, twins, compatriots