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中国浙江一起重症日本斑点热病例
Authors Zhou Y , Wang Q, Shen Y, Shen B, Zhang Y, Wang W , Li X
Received 14 February 2023
Accepted for publication 18 May 2023
Published 1 June 2023 Volume 2023:16 Pages 3425—3430
DOI https://doi.org/10.2147/IDR.S408499
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Suresh Antony
Background: Japanese spotted fever (JSF) is a rare disease, caused by Rickettsia japonica ; no case has been reported in Zhejiang Province, China.
Case Presentation: An elderly woman presented to the hospital with abdominal pain and fever. Her condition rapidly worsened with severe complications, such as multiple organ failure and central nervous system damage. The presence of R. japonica was quickly detected by metagenomic next-generation sequencing. On the basis of combined clinical manifestations and laboratory results, critical JSF was diagnosed and treated with doxycycline. The patient showed good prognosis. Typical symptoms (eschar and rash) were not observed in the early stage, consequently increasing the difficulty of clinical diagnosis.
Conclusion: The delay of treatment caused by non-specific symptoms is an important factor affecting the progression of JSF. As an emerging pathogen detection method, mNGS has been successfully applied for disease diagnosis and treatment, and can be an important complement for the diagnosis of this disease.
Keywords: Japanese spotted fever, Rickettsia japonica , spotted fever group Rickettsia, mNGS, fever, multiple organ failure, central nervous system damage