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细胞外囊泡的治疗应用进展
Authors Zhang Y, Dou Y, Liu Y, Di M, Bian H, Sun X , Yang Q
Received 22 February 2023
Accepted for publication 8 June 2023
Published 16 June 2023 Volume 2023:18 Pages 3285—3307
DOI https://doi.org/10.2147/IJN.S409588
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Yan Shen
Abstract: Extracellular vesicles (EVs) are nanoscale bilayer phospholipid membrane vesicles released by cells. Contained large molecules such as nucleic acid, protein, and lipid, EVs are an integral part of cell communication. The contents of EVs vary based on the cell source and play an important role in both pathological and physiological conditions. EVs can be used as drugs or targets in disease treatment, and changes in the contents of EVs can indicate the progression of diseases. In recent years, with the continuous exploration of the structure, characteristics, and functions of EVs, the potential of engineered EVs for drug delivery and therapy being constantly explored. This review provides a brief overview of the structure, characteristics and functions of EVs, summarizes the advanced application of EVs and outlook on the prospect of it. It is our hope that this review will increase understanding of the current development of medical applications of EVs and help us overcome future challenges.
Keywords: extracellular vesicle, nanotherapeutic, disease diagnosis, engineered exosome, advances applications