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骨组织工程设计药物及复合生物材料研究进展
Authors Guo X , Song P, Li F, Yan Q, Bai Y, He J, Che Q, Cao H, Guo J, Su Z
Received 4 April 2023
Accepted for publication 13 June 2023
Published 1 July 2023 Volume 2023:18 Pages 3595—3622
DOI https://doi.org/10.2147/IJN.S415666
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Prof. Dr. Dongwoo Khang
Abstract: Bone, like most organs, has the ability to heal naturally and can be repaired slowly when it is slightly injured. However, in the case of bone defects caused by diseases or large shocks, surgical intervention and treatment of bone substitutes are needed, and drugs are actively matched to promote osteogenesis or prevent infection. Oral administration or injection for systemic therapy is a common way of administration in clinic, although it is not suitable for the long treatment cycle of bone tissue, and the drugs cannot exert the greatest effect or even produce toxic and side effects. In order to solve this problem, the structure or carrier simulating natural bone tissue is constructed to control the loading or release of the preparation with osteogenic potential, thus accelerating the repair of bone defect. Bioactive materials provide potential advantages for bone tissue regeneration, such as physical support, cell coverage and growth factors. In this review, we discuss the application of bone scaffolds with different structural characteristics made of polymers, ceramics and other composite materials in bone regeneration engineering and drug release, and look forward to its prospect.
Keywords: bone scaffold, drug loading, slow release, osteogenesis, biomaterial