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冠心病合并消化道出血患者血液分离一株混淆韦斯氏菌
Authors Wang X, Zhang D, Dai Z, Yu J, Li Q, Zhang L
Received 16 May 2023
Accepted for publication 5 July 2023
Published 13 July 2023 Volume 2023:16 Pages 4571—4577
DOI https://doi.org/10.2147/IDR.S418755
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Suresh Antony
Introduction: W. confusa has been known to cause various human infections. It is naturally resistant to vancomycin and is difficult to identify using traditional methods, which may lead to misidentification and delay treatment.
Case Presentation: We present a case of a 42-year-old male patient with gastrointestinal bleeding and coronary heart disease who developed sepsis caused by Weissella confusa . The patient’s blood cultures showed the presence of gram-positive coccobacilli, later identified as W. confusa through matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Antimicrobial susceptibility testing revealed that W. confusa had low minimum inhibitory concentrations (MICs) for some drugs (eg, ampicillin) and higher MICs for others (eg, cefotaxime). Empirical treatment with vancomycin was initially started, but after obtaining the identification and susceptibility results, the treatment was switched to meropenem combined with daptomycin, resulting in a successful outcome.
Conclusion: Weissella confusa bacteremia is relatively rare, and accurate pathogenic diagnosis is essential for effective clinical treatment.
Keywords: Weissella confusa , bacterial identification, 16S rRNA, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry