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系统性红斑狼疮患者合并马尔尼菲踝节菌和耶氏肺孢子虫感染
Authors Chen R , Li X, Zheng D, Cao C, Su J
Received 3 April 2023
Accepted for publication 21 June 2023
Published 27 July 2023 Volume 2023:16 Pages 4913—4918
DOI https://doi.org/10.2147/IDR.S414763
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Suresh Antony
Abstract: Talaromyces marneffei (TM) and Pneumocystis jirovecii (PJ) infection are opportunistic infections that typically affect individuals with compromised immune systems, such as those with HIV or immunodeficiency. However, these infections are rarely seen in patients with systemic lupus erythematosus (SLE). We present a case study of a 52-year-old woman diagnosed with SLE who developed a co-infection of TM and PJ after receiving glucocorticoids, mycophenolate mofetil (MMF), and belimumab therapy. The patient’s pneumonia improved following treatment with voriconazole, clarithromycin, and compound sulfamethoxazole. This case highlights the potential risk of serious opportunistic infections in SLE patients receiving a combination of glucocorticoids, MMF, and belimumab. Close monitoring of lymphocyte count, immunoglobulin levels, and chest computed tomography scans can aid in the early detection of infections. To the best of our knowledge, this is the first reported case of TM and PJ co-infection in an SLE patient.
Keywords: Talaromyces marneffei , Pneumocystis jirovecii , systemic lupus erythematosus, co-infection, belimumab