论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
流感嗜血杆菌的流行趋势和生物膜形成机制:洞察临床意义和预防策略
Authors Xiao J, Su L, Huang S , Liu L, Ali K , Chen Z
Received 5 June 2023
Accepted for publication 10 August 2023
Published 16 August 2023 Volume 2023:16 Pages 5359—5373
DOI https://doi.org/10.2147/IDR.S424468
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Suresh Antony
Abstract: Haemophilus influenzae (H. influenzae ) is a significant pathogen responsible for causing respiratory tract infections and invasive diseases, leading to a considerable disease burden. The Haemophilus influenzae type b (Hib) conjugate vaccine has notably decreased the incidence of severe infections caused by Hib strains, and other non-typable H. influenzae (NTHi) serotypes have emerged as epidemic strains worldwide. As a result, the global epidemic trends and antibiotic resistance characteristics of H. influenzae have been altered. Researches on the virulence factors of H. influenzae , particularly the mechanisms underlying biofilm formation, and the development of anti-biofilm strategies hold significant clinical value. This article provides a summary of the epidemic trends, typing methods, virulence factors, biofilm formation mechanisms, and prevention strategies of H. influenzae . The increasing prevalence of NTHi strains and antibiotic resistance among H. influenzae , especially the high β-lactamase positivity and the emergence of BLNAR strains have increased clinical difficulties. Understanding its virulence factors, especially the formation mechanism of biofilm, and formulating effective anti-biofilm strategies may help to reduce the clinical impact. Therefore, future research efforts should focus on developing new approaches to prevent and control H. influenzae infections.
Keywords: Haemophilus influenzae , epidemiology, virulence factors, biofilms, prevention strategies