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与寻常痤疮相关的基因变异
Received 18 May 2023
Accepted for publication 11 August 2023
Published 28 August 2023 Volume 2023:16 Pages 3843—3856
DOI https://doi.org/10.2147/IJGM.S421835
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Scott Fraser
Abstract: Acne vulgaris (AV) ranks among the common chronic inflammatory disorders that impact the sebaceous components of hair follicles. Acne vulgaris is characterised by cardinal manifestations such as the presence of pimples, nodules, pustules, and cysts, which have the potential to lead to the development of acne scarring and pigmentation. The phenomenon is influenced by polygenic inheritance or can be ascribed to the interplay between multiple genes and environmental factors. In recent years, some researchers have found that some genes (such as IL, TNF, RETN, CYP family, MMPs and TIMPs genes et al) are associated with acne vulgaris and may affect the progression and prognosis of the disease. The number of reviews addressing acne-associated genetic variants, however, is limited. In that case, we have compiled a list of prevalent genes associated with acne in recent times. This helps us understand acne’s genetic basis and lets us step in early for people prone to severe acne, lowering the chance of acne scars.
Keywords: acne vulgaris, susceptible genes, genetic variants, genetics