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2022 年中国上海感染 SARS-CoV-2 Omicron BA.2 的既往过敏患者,病毒载量较高且恢复天数较长
Authors Wen R, Li J, Wang X, Xu P, Li G, Wang J, Zeng X , Liu C
Received 13 January 2023
Accepted for publication 12 June 2023
Published 1 September 2023 Volume 2023:16 Pages 903—913
DOI https://doi.org/10.2147/JAA.S402674
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Luis Garcia-Marcos
Background: It is not known whether the viral load and the number of days to negative nucleic acid increased in patients with a history of allergy during the COVID-19 pandemic.
Objective: To investigate the impact of allergy labels on SARS-CoV-2 Omicron outcomes.
Methods: This retrospective cohort study included 62,293 patients with mild Omicron infection between April 9, 2022, and May 31, 2022. Using 1:2 propensity score matching, we identified 2177 COVID-19 patients with a history of allergy and 4254 COVID-19 patients with no history of allergy. The differences in viral load, days to nucleic acid turning negative, and clinical symptoms were compared between the two groups.
Results: Compared with the group with no allergies, the number of days before negative nucleic acid conversion of COVID-19 patients with allergies was significantly higher, the viral load was significantly higher, and the cumulative negative conversion rates at 5– 10 days were all lower (p < 0.01). Patients with a history of allergy to antibiotics had higher viral load and more days with negative nucleic acid levels (p < 0.001). Subgroup analysis revealed that the viral load in penicillin-allergic and cephalosporins-allergic patients was significantly compared to patients without any history of allergies (p < 0.05).
Conclusion: Patients with a history of allergy have a more significant viral load and a longer duration of nucleic acid negative conversion upon COVID-19 infection, particularly those allergic to antibiotics.
Keywords: COVID-19, omicron, allergy history, antibiotics allergy, ct value, nucleic acid turning-negative-time