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中国老年患者引起心内膜炎的人畜共患病原体 ST1 汉赛巴尔通体的基因组分析
Authors Mu X, Liang J, Qian L, Zhou B, Zou X , Fu Y, Zhu Y, Li X , Shi J
Received 15 June 2023
Accepted for publication 29 August 2023
Published 11 September 2023 Volume 2023:16 Pages 6079—6084
DOI https://doi.org/10.2147/IDR.S422345
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Sandip Patil
Abstract: Infective endocarditis (IE) is a rare disease but with high associated mortality. Currently, the mainstays of diagnosis are still echocardiography and blood cultures. Here, we reported a case of infective endocarditis with negative blood cultures, and blood and aortic valve tissue metagenomic next-generation sequencing (mNGS) results suggested Bartonella henselae . In addition, we obtained the whole genomic sequence of B. henselae ZJBH strain. To our knowledge, this is the first report of B. henselae genomic analysis isolated from clinic in China. Furthermore, we described the whole genome sequencing (WGS) data incorporating all B. henselae from diverse sources worldwide and shed light on underlying risk of B. henselae transmitted between cats and humans.
Keywords: infective endocarditis, Bartonella henselae , metagenomic next-generation sequencing