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组合会更好吗:游泳运动和间歇性禁食通过 miR-122-5p/SREBP-1c/CPT1A 途径改善肥胖大鼠高脂饮食诱发的非酒精性脂肪肝病
Authors Yang K , Liu C, Shao J, Guo L, Wang Q, Meng Z, Jin X, Chen X
Received 17 November 2023
Accepted for publication 12 March 2024
Published 12 April 2024 Volume 2024:17 Pages 1675—1686
DOI https://doi.org/10.2147/DMSO.S448165
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Konstantinos Tziomalos
Background: Swimming and intermittent fasting can both improve obesity-induced NAFLD, but which of the two is more effective and whether the combination of the two has a superimposed effect is inconclusive.
Methods: The model of NAFLD in obese rats was established by a high-fat diet and performed swimming, intermittent fasting, and a combination of both interventions for 8 weeks. Serum lipids and enzyme activity were measured by an automatic biochemical analyzer. Liver morphostructural analysis was observed by transmission electron microscopy, and morphology was observed by HE staining. RT‒PCR was used to detect the mRNA level.
Results: Morphology and microstructure of the liver of model rats were impaired, with the upregulation of miR-122-5p, SREBP-1c, FASN and ACC1. Eight weeks of swimming exercise, intermittent fasting and the combination of both attenuate these effects, manifested by the downregulation of miR-122-5p and upregulation of CPT1A mRNA levels. There was no significant stacking effect of the combination of the swimming and intermittent fasting interventions.
Conclusion: NAFLD leads to pathology in model rats. Eight weeks of swimming exercise, intermittent fasting and the combination of both can inhibit miR-122-5p and improve hepatic lipid metabolism, while no significant additive effects of combining the interventions were found.
Keywords: obesity, NAFLD, swimming, intermittent fasting, miR-122-5p