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PD-1 阻断引起的噬血细胞性淋巴组织细胞增多症,2 例 CAEBV 患者的治疗结果陷入困境:病例系列
Authors Chen L, Wang J, Wang Z
Received 20 October 2023
Accepted for publication 4 April 2024
Published 18 April 2024 Volume 2024:17 Pages 1545—1550
DOI https://doi.org/10.2147/IDR.S441460
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Héctor Mora-Montes
LeiLei Chen, Jingshi Wang, Zhao Wang
Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China
Correspondence: Zhao Wang, Capital Medical University, Beijing, People’s Republic of China, Email wangzhao@ccmu.edu.cn
Abstract: Hemophagocytic lymphohistiocytosis (HLH), whether primary or secondary, is a rare and fatal clinical syndrome of uncontrolled immune activation and inflammatory cascade. Immune checkpoint inhibitors (ICIs) induced HLH has no standard diagnostic and treatment guidelines. Early diagnosis and appropriate treatment according to different disease backgrounds are crucial. Herein, we first report 2 cases of patients with chronic active Epstein-Barr virus infection (CAEBV) who developed HLH after the use of sintilimab, a monoclonal antibody against programmed cell death protein 1 (PD-1), and the DEP (liposomal doxorubicin, etoposide, methylprednisolone) chemotherapy regimen in combination with ruxolitinib were used to successfully control the disease.
Keywords: PD-1 blockade, hemophagocytic lymphohistiocytosis, CAEBV, case report case series