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Authors Zhu CY, Xiao JJ, Tang M, Feng H, Chen WL, Du M
Received 22 December 2016
Accepted for publication 18 April 2017
Published 12 May 2017 Volume 2017:12 Pages 3697—3710
DOI https://doi.org/10.2147/IJN.S130938
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Abstract: The preparation of polymer therapeutics capable of controlled release of
multiple chemotherapeutic drugs has remained a tough problem in synergistic
combination cancer therapy. Herein, a novel dual-drug co-delivery system
carrying doxorubicin (DOX) and platinum(IV) (Pt[IV]) was developed. An
amphiphilic diblock copolymer, PCL-b-P(OEGMA-co-AzPMA), was synthesized and
used as a nanoscale drug carrier in which DOX and Pt(IV) could be packaged
together. The copolymers were shell cross-linked by Pt(IV) prodrug via a click
reaction. Studies on the in vitro drug release and cellular uptake of the
dual-drug co-delivery system showed that the micelles were effectively taken up
by the cells and simultaneously released drugs in the cells. Futhermore, the
co-delivery polymer nanoparticles caused much higher cell death in HeLa and
A357 tumor cells than either the free drugs or single-drug-loaded micelles at
the same dosage, exhibiting a synergistic combination of DOX and Pt(IV). The
results obtained with the shell cross-linked micelles based on an anticancer
drug used as a cross-linking linkage suggested a promising application of the
micelles for multidrug delivery in combination cancer therapy.
Keywords: dual-drug co-delivery system,
amphiphilic diblock copolymer, shell cross-linked micelles, synergistic
combination cancer therapy