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Authors Teliewubai J, Bai B, Zhou Y, Lu Y, Yu S, Chi C, Li J, Blacher J, Xu Y, Zhang Y
Received 30 October 2017
Accepted for publication 9 January 2018
Published 6 March 2018 Volume 2018:13 Pages 389—395
DOI https://doi.org/10.2147/CIA.S155514
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Wu
Objective: Secreted frizzled related protein 5 (SFRP5) is a novel
anti-inflammatory adipokine that is implicated in metabolic and cardiovascular
disease (CVD). However, little is known about the relevance of SFRP5 with
asymptomatic hypertensive target organ damages (TODs). We aimed to investigate
the association between SFRP5 and TOD in a large population.
Clinical trial
registration: NCT02368938.
Methods: A total of 1,745 community-dwelling elderly subjects aged over 65
years from northern Shanghai were recruited in the study. Plasma SFRP5 level
was measured by an enzyme-linked immunosorbent assay. Asymptomatic TODs,
including left ventricular mass index, peak transmitral pulsed Doppler
velocity/early diastolic tissue Doppler velocity, carotid intima–media
thickness (CIMT), pulse wave velocity (PWV), estimated glomerular filtration
rate, and urinary albumin–creatinine ratio were evaluated.
Results: Plasma SFRP5 level was negatively associated with body mass index,
waist/hip ratio, and fasting blood glucose (all P <0.001). Men, compared with
women, had lower plasma SFRP5 level (4.19 vs 5.13 ng/mL, P <0.001). Additionally, plasma
SFRP5 level was lower in diabetics than in those without diabetes (4.30 vs 4.81
ng/mL, P <0.05). Furthermore, an
inverse association was observed between SFRP5 and PWV and CIMT (both P <0.05). Lastly, the
multivariate logistic regression analysis showed lower SFRP5 level was
significantly associated with increased arterial stiffness in the elderly (odds
ratio 0.83, 95% confidence interval 0.71 to 0.99 per 1 standard deviation
increase, P <0.05).
Conclusion: Plasma SFRP5 level was inversely correlated with conventional
cardiovascular risk factors, and low plasma SFRP5 was also significantly
associated with arterial stiffening in the elderly Chinese population.
Keywords: secreted frizzled related protein 5, cardiovascular disease,
asymptomatic target organ damage, arterial stiffness