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Authors Lu T, Wang Y, Chen D, Liu J, Jiao W
Received 27 June 2018
Accepted for publication 12 October 2018
Published 13 November 2018 Volume 2018:11 Pages 8045—8052
DOI https://doi.org/10.2147/OTT.S178431
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 3
Editor who approved publication: Dr Sanjeev Srivastava
Abstract: Lung cancer has
been identified as one of the most prevalent and deadly tumors worldwide. In
recent years, lncRNAs have been demonstrated to play a significant role in the
development of lung cancer. Specifically, lncRNAs act as a regulator of
cancer-critical genes, and they regulate the biological behavior of tumors at
the transcriptional and posttranscriptional levels. Recent studies have shown
that lncRNAs possess great potential in the treatment of non-small cell lung
cancer patients because of their roles in diverse cellular processes, such as
proliferation, metastasis, stem cell maintenance, and epithelial to mesenchymal
transition, and they serve as signaling biomarkers. Compared to other invasive
diagnostic methods, detection of lncRNAs may become a very useful noninvasive
methodology. Moreover, lncRNAs can serve as potential therapeutic targets in
non-small cell lung cancer due to their roles in regulating many signaling
pathways associated with lung carcinoma. In this review, we discuss the roles
and expression profile of lncRNAs. We also discuss the promising application of
lncRNAs as predictors of clinical diagnosis, prognosis, and as potential
therapeutic targets, aiming to demonstrate their practical value for clinical
treatment.
Keywords: biomarker,
lncRNA, diagnosis, prognosis, therapy, NSCLC