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Authors Sun JJ, Liu XM, Shen CY, Feng K, Liu PZ
Received 2 June 2018
Accepted for publication 26 September 2018
Published 13 November 2018 Volume 2018:14 Pages 3081—3090
DOI https://doi.org/10.2147/NDT.S176153
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Justinn Cochran
Peer reviewer comments 2
Editor who approved publication: Dr Yu-Ping Ning
Purpose: Bipolar
disorder (BD) patients with psychotic symptoms (BDp) worsens prognosis and
decreases rates of recovery. The study investigated cognitive performance and
brain function between BD patients in depressive episode with and without
psychotic symptoms to find potential neurobiological markers associated with
psychotic features of BD patients in depressive episode.
Patients and methods: Thirty-one
patients without psychotic symptoms and 29 patients with psychotic symptoms
diagnosed with bipolar I disorder with a current depressive episode were
included in the present study. The neural function of prefrontal cortex (PFC)
and cognitive performance among BDp, BD patients without psychotic symptoms,
and 23 healthy controls (HC) were examined using near-infrared spectroscopy
during verbal fluency task (VFT).
Results: 1) Both
the BD groups exhibited significantly worse performance of VFT and lower
activation of oxygenated hemoglobin (oxy-Hb) changes in the bilateral
ventrolateral PFC compared with the HC group. 2) Within the BD group, VFT
performance was not significantly different. 3) The prefrontal activation of
oxy-Hb changes in the BDp patients was significantly lower than that in the BD
patients without psychotic symptoms in the right dorsolateral PFC. 4)
Activation of oxy-Hb changes in right dorsolateral PFC was negatively
correlated with the severity of psychotic symptoms in BDp patients.
Conclusion: The
prefrontal function differs between BD patients in depressive episode with or
without psychotic symptoms measured with near-infrared spectroscopy.
Keywords: bipolar
disorder, depressive, psychotic symptoms, near-infrared spectroscopy, verbal
fluency task