论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
Authors Lan M, Zipu J, Ying S, Hao R, Fang L
Received 5 July 2018
Accepted for publication 3 September 2018
Published 19 November 2018 Volume 2018:11 Pages 2877—2885
DOI https://doi.org/10.2147/JPR.S179228
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr E Alfonso Romero-Sandoval
Background: There is
a lack of prospective studies for the long-term results of percutaneous pulsed
radiofrequency (PRF) of the Gasserian ganglion in the treatment of patients
with medically refractory trigeminal neuralgia (TN).
Methods and results: We
prospectively observed the outcomes of 28 idiopathic TN patients (between July
2013 and July 2016) who received CT-guided percutaneous PRF treatment of the
Gasserian ganglion. All of the patients had stopped responding to drug therapy
before PRF treatment. The effective treatment standard was a reduction in the
pain numeric rating scale (NRS) by ≥50% after the procedure. The
postoperative NRS score decreased gradually from preoperative 7.6±0.8 months to
1.5±2.4, 0.2±0.4, 0.2±0.4, 0.1±0.4, and 0.1±0.4 at 1, 3, and 6 months and 1 and
2 years after the PRF treatment. The response rates at 1, 3, and 6 months were
85.7%, and the rates at 12 months and 2 years were maintained at 78.6%. No
serious side effects were observed.
Conclusion: CT-guided PRF
invention is an effective and safe technique for medically intractable
idiopathic TN patients. This minimally invasive alternative treatment has the
potential as a first-line therapy for TN.
Keywords: trigeminal
neuralgia, pulsed radiofrequency, efficacy, safety