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Authors Chen Z, Han C, Huang X, Liu Y, Guo D, Ye X
Received 28 June 2018
Accepted for publication 16 September 2018
Published 20 November 2018 Volume 2018:11 Pages 2363—2375
DOI https://doi.org/10.2147/IDR.S178584
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 4
Editor who approved publication: Professor Suresh Antony
Background: Methicillin-resistant Staphylococcus aureus (MRSA)
causes a wide variety of serious infections worldwide. There are few studies on
the prevalence, antimicrobial susceptibility, and molecular characteristics of
MRSA contamination in the environment of airports.
Materials and methods: A
cross-sectional survey was conducted in Guangzhou Baiyun Airport. Environmental
surface sampling was conducted in frequently touched locations for S. aureus analysis.
All isolates were characterized by multilocus sequence typing (MLST) and tested
for antimicrobial susceptibility, resistance genes, and virulence genes. Data
were analyzed by chi-squared test and correspondence analysis.
Results: Of the
1,054 surface samples, the contamination rate was 7.2% (76/1,054) for S. aureus and 2.2%
(23/1,054) for MRSA. There were 62.9% (56/89) S. aureus isolates
classified as multidrug resistant (MDR), with six linezolid-resistant isolates
and two cfr -carrying
isolates. The most prevalent S. aureus genotypes were CC6 (ST6), CC59 (ST59),
and CC188 (ST188), with ST59-MRSA-IV (pvl –) as the predominant MRSA. There were significant
differences between methicillin-resistant and methicillin-sensitive isolates in
rates of resistance to tetracycline (P <0.001) and sek carriage (P =0.029). The
correspondence analyses revealed significant corresponding relationships
between genotypes and phenotype–genotype characteristics of S. aureus isolates.
Conclusion: Our findings
revealed a potential risk of cross-transmission of MRSA between human beings
and environments, suggesting more stringent contamination control measures. In
addition, this study revealed significant corresponding relationships between
genotypes and phenotype–genotype characteristics of S. aureus isolates,
which may provide new ideas for monitoring the latest epidemiological trends.
Keywords: Staphylococcus aureus ,
methicillin-resistant S. aureus , environment, molecular characterization,
antimicrobial susceptibility