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Authors Liu MR, Xu CH, Sun YY
Received 12 October 2018
Accepted for publication 6 December 2018
Published 28 December 2018 Volume 2019:13 Pages 183—203
DOI https://doi.org/10.2147/DDDT.S190674
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Tuo Deng
Objective: To
systematically evaluate the efficacy and safety of sodium cantharidinate and
vitamin B6 (SC/B6) combined with conventional medical treatment (CMT) for the
treatment of patients with advanced digestive system neoplasms (DSNs).
Methods: The
Cochrane Library, Embase, PubMed, Web of Science, Chinese Scientific Journal
Database (VIP), China National Knowledge Infrastructure, and Wanfang databases
were searched for clinical trials using SC/B6 for DSNs. Outcome measures,
including therapeutic efficacy, quality of life (QoL), and adverse events, were
extracted and systematically evaluated.
Results: Data from
24 trials including 1,825 advanced DSN patients were included. Compared with
CMT alone, its combination with SC/B6 significantly improved the patients’
overall response rate (OR =2.25, 95% CI =1.83–2.76, P <0.00001),
disease control rate (OR =2.41, 95% CI =1.85–3.15, P <0.00001), and
QoL improvement rate (OR =2.75, 95% CI =2.13–3.55, P <0.00001).
Moreover, adverse events caused by chemotherapy, including leukopenia, nausea
and vomiting, gastrointestinal side effects, hepatotoxicity, diarrhea,
transaminase disorder, myelosuppression, anorexia, and anemia, were
significantly alleviated (P <0.05) when SC/B6 was applied to DSN patients.
Nephrotoxicity, thrombocytopenia, hand-foot syndrome, and oral mucositis were
not significantly alleviated in patients receiving combination therapy (P >0.05).
Conclusion: The
combination of SC/B6 and CMT is more effective in treating DSNs than CMT alone.
This combination alleviates the adverse effects associated with chemotherapy
and improves the QoL of DSN patients, and its application in the clinic is
worth promoting.
Keywords: sodium
cantharidinate and vitamin B6, conventional medical treatment, digestive system
neoplasms, meta-analysis