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Authors Chen Z, Hu B, Feng Y, Wang Z, Jiang X, Cheng Y, He D, Zhu D, Xiao Z, Wang H, Mao Z
Received 30 August 2018
Accepted for publication 4 December 2018
Published 28 December 2018 Volume 2019:15 Pages 65—72
DOI https://doi.org/10.2147/TCRM.S185929
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Professor Deyun Wang
Purpose: To
investigate the incidence and risk factors for early repolarization (ER) in
patients with growth hormone (GH)-secreting pituitary adenomas.
Methods: From August
2014 to August 2016, patients with GH-secreting pituitary adenomas and
non-functioning pituitary adenomas admitted to the First Affiliated Hospital,
Sun Yat-sen University, were prospectively enrolled. Logistic regression
analysis was used to investigate risk factors for ER development.
Results: A total of 118
patients with GH-secreting pituitary adenomas (41 with concomitant ER) and 103
patients with non-functioning pituitary adenomas were included. Compared with
the non-functioning adenoma group GH and IGF-1 levels, left ventricular mass
index (LVMI), and incidence of ER were significantly higher in the GH-secreting
pituitary adenoma group (all P <0.05). LVMI was an independent risk factor for
ER. Bivariate correlation analysis showed that course of disease, GH, IGF-1,
and diabetes were correlated with LVMI. Course of disease and IGF-1 were
directly correlated with LVMI. Two-year follow-up of patients who underwent
transsphenoidal resection showed that incidence of ER was significantly
decreased in patients with normal GH and IGF-1 levels.
Conclusion: Compared
with non-functioning pituitary adenoma patients, patients with GH-secreting
pituitary adenomas have a significantly higher incidence of ER. Elevation of
serum GH and IGF-1 had positive correlations with cardiac muscle cell
hypertrophy and increased LVMI.
Keywords: pituitary
tumors, growth hormone-secreting pituitary adenoma, insulin-like growth factor,
left ventricle mass index, early repolarization