论文已发表
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Authors An C, Li X, Liang P, Yu J, Cheng Z, Han Z, Liu F, Dong L
Received 20 November 2018
Accepted for publication 23 January 2019
Published 15 February 2019 Volume 2019:11 Pages 1569—1578
DOI https://doi.org/10.2147/CMAR.S195354
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 4
Editor who approved publication: Dr Antonella D'Anneo
Purpose: This
study aimed to investigate the clinical value of a tumor map for assessing the
ablative effect after ultrasound-guided percutaneous microwave ablation
(US-PMWA) for hepatocellular carcinoma (HCC).
Methods: The
medical records of 68 patients (49 male and 19 female, 59.9±12.7 years) with
HCC who underwent US-PMWA from May 2013 to May 2017 were reviewed. A tumor map
was generated from the fusion of three-dimensional (3D) visualization images
based on the preoperative target tumor and postoperative ablation area, to
evaluate whether the ablation area covering the tumor has reached a 5 mm
ablative margin (AM). The lesions were divided into two groups according to the
tumor maps: group A (failed to achieve AM) and group B (achieved AM). The
cumulative local tumor progression (LTP) rates of both groups were
statistically analyzed using the log-rank test.
Results: Success
rate of tumor map generation was 100% (68/68), and no residual tumors were
found. MWA-related 3D images, which included target tumor volume, ablation area
volume, and residual liver ratio, were compared between groups A and B (P =0.295, P =0.772, and P =0.527,
respectively). Technique effectiveness rate (91.7% vs 100%) was achieved in the
two groups, showing no significant statistical differences (P =0.672). The 3-,
6-, 9-, and 12-month LTP rate was 8.3%, 16.7%, 20.8%, and 34%, respectively,
for group A and 0%, 2.8%, 2.8%, and 2.8%, respectively, for group B, showing
significant statistical differences (P <0.001) between the two groups.
Conclusion: The novel
technology of tumor map generated from 3D visualization of image fusion is
feasible and useful in evaluating the ablative effect of US-PMWA for HCC.
Keywords: three-dimensional
visualization, tumor map, image fusion, microwave ablation, hepatocellular
carcinoma