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Authors Ma J, Deng H, Li J, Hu S, Yang Y, Liu S, Han X
Received 16 October 2018
Accepted for publication 4 February 2019
Published 16 April 2019 Volume 2019:11 Pages 3061—3078
DOI https://doi.org/10.2147/CMAR.S191107
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Professor Nakshatri
Background: Olaparib,
a potent oral poly (ADP-ribose) polymerase inhibitor, exhibits antitumor
activity and prevents the recurrence in advanced ovarian cancer. In this
article, we assessed the efficacy and safety of olaparib maintenance therapy on
platinum-sensitive ovarian cancer patients with BRCA mutations
through a meta-analysis of available randomized controlled trials (RCTs) to
provide more evidence for its clinical applications.
Methods: We
searched PubMed, Embase, Wanfang, CNKI, Web of Science, Cochrane Library, and
VIP databases from 1 August 2018 to identify RCTs and finally included four
RCTs (seven articles) with 567 eligible participants beyond the participants,
interventions, comparisons, outcomes, and study design regulation. The outcomes
of olaparib efficacy including progression-free survival (PFS) and overall
survival (OS) were measured by HR and 95% CI, while the quality of life was
evaluated by calculating the combination of P -value. Seven
common adverse events were tested by risk ratio and 95% CI as the outcomes of
olaparib safety. These data were analyzed, and the forest figures were produced
using Review Manager 5.3.
Results: Compared
with other interventions (ie, placebo or chemotherapy drugs), olaparib
significantly prolonged PFS (HR=0.31, 95% CI=0.15–0.62) and slightly improved
OS (HR=0.75, 95% CI=0.56–0.99), but did not influence the quality of life (P =0.058) in the
patients with platinum-sensitive BRCA -mutated ovarian cancer. Additionally, the
toxicity profile of olaparib involved anemia, fatigue, vomiting, diarrhea, and
nausea with grade 1–2.
Conclusion: This meta-analysis
suggests that olaparib maintenance therapy is effective and well-tolerated for
the patients with platinum-sensitive BRCA -mutated ovarian cancer. More updated RCTs and
long-term follow-up should be conducted to compare and analyze the efficacy and
toxicity of olaparib at different doses in ovarian cancer patients.
Keywords: olaparib,
ovarian cancer, efficacy, adverse event, meta-analysis