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Authors Li Z, Xu Z, Huang Y, Zhao R, Cui Y, Zhou Y, Wu X
Received 19 October 2018
Accepted for publication 12 March 2019
Published 16 April 2019 Volume 2019:11 Pages 3265—3274
DOI https://doi.org/10.2147/CMAR.S191432
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Andrew Yee
Peer reviewer comments 2
Editor who approved publication: Dr Antonella D'Anneo
Purpose: Preoperative
platelet-to-monocyte ratio (PLR), albumin and hemoglobin are suggested
prognostic indicators in various malignancies. However, the prognostic values
of PLR, albumin and hemoglobin remain elusive. The objective of the present
study was to evaluate the prognostic values of PLR, albumin and hemoglobin in
stage I-III colon cancer.
Patients and methods: A total
of 312 patients with non-metastatic colon cancer undergoing curative resection
were enrolled in this study. The prognostic values of PLR, albumin and
hemoglobin were identified by receiver operating characteristics, and
univariate and multivariate analyses.
Results: Univariate
analysis revealed that preoperative PLR, albumin and hemoglobin were
significantly associated with overall survival (OS) and that preoperative PLR
and albumin were significantly associated with progression-free survival (PFS).
Multivariate analysis revealed that preoperative PLR was significantly
associated with OS.
Conclusion: Reduced
preoperative PLR was significantly associated with better OS in patients with
stage I-III colon cancer. Preoperative PLR was an independent prognostic
indictor for OS in patients with colon cancer undergoing curative resection.
Keywords: platelet-to-lymphocyte
ratio, albumin, hemoglobin, colon cancer, prognosis