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Authors Song J, Zhang N, Zhang L, Yi H, Liu Y, Li Y, Li X, Wu M, Hao L, Yang Z, Wang Z
Received 28 January 2019
Accepted for publication 21 March 2019
Published 18 April 2019 Volume 2019:14 Pages 2757—2772
DOI https://doi.org/10.2147/IJN.S203108
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Alexander Kharlamov
Peer reviewer comments 2
Editor who approved publication: Dr Mian Wang
Background and purpose: Surgery
is regarded as the gold standard for patients with advanced ovarian cancer.
However, complete surgical removal of tumors remains extremely challenging;
fewer than 40% of patients are cured. Here, we developed a new modality of
theranostics for ovarian cancer based on a near-infrared light-triggered
nanoparticle.
Methods: Nanoparticles
loading IR780 iodide on base of folate modified liposomes were prepared and
used for theranostics of ovarian cancer. Tumor targeting of FA-IR780-NP was
evaluated in vitro and in an ovarian xenograft tumor model. A fluorescence
stereomicroscope was applied to evaluate the tumor recognition of FA-IR780-NP
during surgery. FA-IR780-NP mediated photothermal therapy effect was compared
with other treatments in vivo.
Results: FA-IR780-NP
was demonstrated to specifically accumulate in tumors. IR780 iodide selectively
accumulated in tumors; the enhanced permeability and retention effect of the
nanoparticles and the active targeting of folate contributed to the excellent
tumor targeting of FA-IR780-NP. With the aid of tumor targeting, FA-IR780-NP
could be used as an indicator for the real-time delineation of tumor margins
during surgery. Furthermore, photothermal therapy mediated by FA-IR780-NP
effectively eradicated ovarian cancer tumors compared with other groups.
Conclusion: In this
study, we present a potential, effective approach for ovarian cancer treatment
through near-infrared fluorescence image-guided resection and photothermal
therapy to eliminate malignant tissue.
Keywords: ovarian
cancer, imaged-guide surgery, IR780 iodide, photothermal therapy, nanomedicine