论文已发表
注册即可获取德孚的最新动态
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Authors Wang Y, Li S, Hu X, Wang Y, Wu Y, Li P, Che G
Received 18 October 2018
Accepted for publication 6 March 2019
Published 24 April 2019 Volume 2019:11 Pages 3545—3554
DOI https://doi.org/10.2147/CMAR.S191288
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Ms Justinn Cochran
Peer reviewer comments 2
Editor who approved publication: Dr Ahmet Emre Eskazan
Background: Previous
studies demonstrated a significant association between the albumin–globulin
ratio (AGR) and various types of cancers. The aim of this study was to evaluate
the prognostic value of preoperative AGR in patients with early-stage non-small
cell lung cancer (NSCLC).
Methods: Patients
diagnosed as NSCLC in a single center between January 1, 2014 and February 29,
2016 were retrospectively reviewed. AGR was defined as the ratio between the
serum albumin level and the serum globulin level. Receiver operating
characteristics analysis was performed to determine optimal cutoff values.
Overall survival (OS) and disease-free survival (DFS) were clinical outcomes of
our study. Univariate and multivariate Cox regression analyses were used to
identify independent prognostic factors, and the Kaplan–Meier method was used
to estimate survival curves.
Results: A total
of 279 early stage NSCLC patients were enrolled in our study with the median
follow-up of 39 months (range 1–56 months). The statistical analyses manifested
that the age (hazard ratio (HR)=1.045, 95% confidence interval (95% CI):
1.010–1.081, P =0.011) and AGR P =0.002) were
independent prognostic factors for OS; larger tumor (HR=1.211, 95% CI:
1.011–1.450, P =0.038) and AGR P =0.036) were
significantly associated with decreased DFS.
Conclusion: The
current research reported that the preoperative AGR was an independent
prognostic factor for both OS and DFS in early NSCLC, and patients with AGR
<1.51 were more likely to have a poor prognosis.
Keywords: albumin-globulin
ratio, early non-small cell lung cancer, overall survival; disease-free
survival