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Authors Huang H, Liao D, Dong Y, Pu R
Received 29 December 2018
Accepted for publication 28 February 2019
Published 24 April 2019 Volume 2019:12 Pages 553—563
DOI https://doi.org/10.2147/DMSO.S199830
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Professor Ming-Hui Zou
Purpose: The
previous investigations which considered the possible effect of the quercetin
supplementation for overweight and obesity have led to inconsistent results.
Here, we aimed to evaluate the effects of quercetin on weight loss using a
meta-analysis of randomized controlled clinical trials (RCTs).
Methods: Relevant
studies were systematically searched from the MEDLINE, EMBASE, Google Scholar,
and Scopus databases. RCTs that investigated the effects of quercetin on weight
loss in humans were included for quality assessment, meta-analyses, sensitivity
analysis, subgroup analyses, and publication bias assessment. Effect size was
expressed as weighted mean difference (WMD) and 95% CI by using a
random-effects model. The Grading of Recommendations Assessment, Development
and Evaluation (GRADE) methodology was used to rate the level of evidence.
Results: Nine RCTs
(11 treatment arms) with 525 participants were finally included for data
pooling. Our meta-analysis revealed that daily quercetin supplementation did
not significantly affect the body weight (WMD: −0.35 kg, 95% CI: −2.03,
1.33; P =0.68),
body mass index (WMD: −0.04 kg/m2, 95% CI: −0.54, 0.45; P =0.87), waist
circumference (WMD: −0.37 cm, 95% CI: −1.81, 1.06; P =0.61), and waist
to hip ratio (WMD: −0.01, 95% CI: −0.03, 0.01; P =0.48). Subgroup
analysis could not identify factors significantly influencing these parameters.
These results were robust in sensitivity analysis, and no significant
publication bias was found.
Conclusion: The
current evidence suggests that quercetin intake did not show a notably
favorable effect on weight loss. Future well-designed and long-term clinical
trials are required to confirm these results.
Keywords: quercetin,
body weight, obesity, overweight, meta-analysis