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Authors Zhang H, Johnson A, Zhang G, Yang Y, Zhang J, Li D, Duan S, Yang Q, Xu Y
Received 30 January 2019
Accepted for publication 15 March 2019
Published 24 April 2019 Volume 2019:12 Pages 905—914
DOI https://doi.org/10.2147/IDR.S203572
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Joachim Wink
Objectives: To update
the epidemiology and susceptibility of hospital-acquired (HA) and
community-acquired (CA), as well as intensive care unit (ICU) vs
non-ICU-derived intra-abdominal infection (IAI) and urinary tract infection
(UTI) pathogens in Chinese hospitals.
Methods: A total
of 2,546 Gram-negative isolates from IAIs and 1,947 isolates from UTIs
collected in 16 hospitals and 7 regions of China from 2016 to 2017 were
analyzed.
Results: E. coli and K. pneumoniae were
the most common pathogens identified in HA (40.7%, 21.9%) and CA (49.2%, 21.3%)
IAIs and in HA (59.0%, 17.3%) and CA (64.3%, 12.7%) UTIs, respectively. The
overall rates of extended-spectrum β-lactamase (ESBL)-positive strains were
48.2% for E.
coli and 26.4% for K. pneumoniae . The rates of ESBL-positive E. coli and K. pneumoniae strains
were significantly higher in HA than in CA IAIs (51.7% vs 42.4%, P =0.016 and 22.0%
vs 20.6%, P <0.001).
IAI E.
coli ESBL-producing isolates were most susceptible to IPM
(97.2%) and AMK (93.9%), and UTI-associated E. coli ESBL-producers
were 94.74% susceptible to amikacin (AMK), 97.02% to imipenem (IPM), and 91.4%
to ertapenem (ETP). IAI K. pneumoniae ESBL-producing isolates were most
susceptible to AMK (84.43%) and IPM (82.79%), and UTI-associated K. pneumoniae ESBL-producers
were 88.39% susceptible to AMK, 87.5% to IPM, and 82.14% to ETP. Overall,
percentages of susceptible strains to ETP, IPM, AMK, and
Piperacillin-Tazobactam (TZP) were in the range of 82.0% to 96.4%, to 5
cephalosporins in the range of 31.4%-69.6% and to 2 fluoroquinolones in the
range of 37.8%-45.5% for E. coli and 65.5%-90.7%, 37.7%-75.3%, and
43.9%-73.2% for K. pneumoniae , respectively.
Conclusion: E. coli and K. pneumoniae continued
to be the main pathogens in Chinese UTIs and IAIs with high ESBL-positive rates
between 2016 and 2017. Carbapenem- or amikacin-based therapies were the most
effective to combat IAI and UTI pathogens.
Keywords: IAI, UTI,
ESBL, E.
coli , K. pneumoniae