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Authors Zhou L, He W, Wang W, Zhou D
Received 8 December 2018
Accepted for publication 30 March 2019
Published 1 May 2019 Volume 2019:12 Pages 3313—3319
DOI https://doi.org/10.2147/OTT.S197507
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 3
Editor who approved publication: Dr Gaetano Romano
Background: Prostate
cancer (PCa), one of the most common cancers in men, accounts for nearly 20% of
adult malignant neoplasms. Omentin-1 is synthesized in visceral adipose tissue
and its concentration in plasma changes with cancers. However, the association
between omentin-1 and PCa was rarely studied. Thus, we investigated the plasma
omentin-1 levels in PCa patients in Chinese population.
Materials and methods: Ninety
cases of PCa and 90 matched healthy controls were enrolled in this study. We
used ELISA technique to determine the concentration of omentin-1.
Results: The
concentration of omentin-1 was higher in patients with PCa compared to controls
(P <0.001).
Additionally, positive correlations were uncovered between omentin-1 with body
mass index (r=0.240, P =0.001), waist-hip ratio (r=0.228, P =0.002), and
prostate-specific antigen (r=0.589, P <0.001). Receiver operating characteristic curve
analysis indicated that plasma omentin-1 differentiated PCa patients from
controls with a sensitivity of 85.9% and a specificity of 83.7%.
Conclusion: Our study
demonstrated that the levels of plasma omentin-1 were increased in PCa
patients. Meanwhile, omentin-1 may be a possible biomarker for diagnosing PCa.
For validation, more studies should focus on and elucidate the potential
mechanism underlying this change.
Keywords: omentin-1,
prostate cancer, obesity, body mass index, adipokines