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毛兰素对抗癌活性影响的进展研究
Authors Zhang Y, Zhang Q, Wei F, Liu N
Received 2 January 2019
Accepted for publication 18 May 2019
Published 9 July 2019 Volume 2019:12 Pages 5457—5465
DOI https://doi.org/10.2147/OTT.S200161
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Ms Shreya Arora
Peer reviewer comments 3
Editor who approved publication: Dr XuYu Yang
Abstract: Erianin is the major bisbenzyl compound extracted from the traditional Chinese medicine Dendrohium chrysotoxum Lindl. Erianin possesses many biological properties relevant to cancer prevention and therapy. The previous studies confirmed that antitumor effects of erianin are regulated with multiple signaling pathways. The mechanisms of erianin are numerous, and most of them induce cancer cell apoptosis that may be intrinsic or extrinsic and modulate the ROS/JNK signaling pathways. Invasion, migration, and angiogenesis represent emerging targets of erianin and support its anticancer properties. This review aimed to summarize the recent advances in the antitumor activity of erianin and to provide a rationale for further exploring the potential application of erianin in overcoming cancer in the future.
Keywords: Erianin, antitumor, apoptosis, cell cycle arrest, molecular mechanism