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中国中南地区男性饮酒,吸烟,槟榔咀嚼和口腔健康与下咽癌相关:病例对照研究
Authors Zeng J, Tang Y, Wu P, Fang X, Wang W, Fan Y, Li X, Zhao S
Received 30 January 2019
Accepted for publication 14 May 2019
Published 10 July 2019 Volume 2019:11 Pages 6353—6364
DOI https://doi.org/10.2147/CMAR.S203439
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Cristina Weinberg
Peer reviewer comments 2
Editor who approved publication: Dr Teng
Background: Hypopharyngeal cancer has relatively high incidence rates in China, especially in high-risk areas. However, data on the role of major risk factors in these areas of China are still limited.
Methods: We have evaluated the roles of alcohol, tobacco and betel quid consumption, and oral health, based on 278 hypopharyngeal cancer cases and 693 controls from two centers in Central South China. The odds ratio (OR) and 95% confidence interval (CI) values were estimated using logistic regression.
Results: We found that alcohol drinkers had a risk of hypopharyngeal cancer that was up to seven times higher than that for those who had never drunk. A very strong effect of traditional liquor as compared to other alcohol types was observed, with the OR reaching 11.26 (CI 6.53–19.41) for this cancer. Tobacco smokers were up to four times more likely to develop hypopharyngeal cancer than never smokers. The OR for betel quid chewing was 1.86 (CI 1.26–2.75) as compared to never users. Poor oral hygiene had a risk of hypopharyngeal cancer that was two times higher than that for normal oral hygiene.
Conclusion: In this study, we have shown for what is believed to be the first time the association of increased hypopharyngeal cancer incidence with alcohol, tobacco, betel quid and oral hygiene in China. Alcohol may play a larger role for hypopharyngeal cancer in this population than in populations in other areas.
Keywords: alcohol, tobacco, betel quid, oral hygiene, hypopharyngeal cancer