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活性氧清除剂虾青素有保护顺铂治疗患者免受听力损失的作用
Authors Nan B, Gu X, Huang X
Received 19 August 2019
Accepted for publication 2 December 2019
Published 18 December 2019 Volume 2019:13 Pages 4291—4303
DOI https://doi.org/10.2147/DDDT.S212313
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Qiongyu Guo
Abstract: Emerging evidence of significant hearing loss occurring shortly after cisplatin administration in cancer patients has stimulated research into the causes and treatment of this side effect. Although the aetiology of cisplatin-induced hearing loss (CIHL) remains unknown, an increasing body of research suggests that it is associated with excessive generation of intracellular reactive oxygen species (ROS) in the cochlea. Astaxanthin, a xanthophyll carotenoid, has powerful anti-oxidant, anti-inflammatory, and anti-apoptotic properties based on its unique cell membrane function, diverse biological activities, and ability to permeate the blood-brain barrier. In this review, we summarize the role of ROS in CIHL and the effect of astaxanthin on inhibiting ROS production. We focus on investigating the mechanism of action of astaxanthin in suppressing excessive production of ROS.
Keywords: astaxanthin, oxidative stress, cisplatin, hearing loss