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亚临床甲状腺功能减退症与睡眠质量之间的关联:一项基于人群的研究
Authors Song L, Lei J, Jiang K, Lei Y, Tang Y, Zhu J, Li Z, Tang H
Received 14 October 2019
Accepted for publication 5 December 2019
Published 19 December 2019 Volume 2019:12 Pages 369—374
DOI https://doi.org/10.2147/RMHP.S234552
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Professor Marco Carotenuto
Background and Aim: The relationship between subclinical hypothyroidism (SHYPO) and sleep quality is still unclear. Our objective was to compare the sleep quality between SHYPO patients and a control group with normal thyroid function.
Methods: A total of 2224 patients with SHYPO and 12,622 euthyroid (EUTH) control group patients were included in the present study. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. The sleep outcomes were compared to explore the association between SHYPO and sleep quality. Furthermore, we tried to identify the risk factors of poor sleep in SHYPO patients.
Results: Compared to the EUTH control patients, SHYPO patients had a higher PSQI score (6.83 ± 2.67 vs 6.64 ± 2.63, p =0.004) and a higher proportion of poor sleepers (67.09% vs 64.75%, p =0.033). Moreover, subjects with SHYPO were associated with poorer sleep (Odd Ratio (OR) 1.120, 95% Confidence Intervals (CI) 1.016 to 1.235, p =0.023), longer sleep latency (OR 1.162, 95% CI 1.053 to 1.282, p =0.003), and shorter sleep duration (OR 1.148, 95% CI 1.019 to 1.293, p =0.023) after adjusting for potential confounders. Furthermore, we found that lower age, lower body mass index, and women were risk factors for poor sleep quality in SHYPO patients.
Conclusion: Our findings suggest a relationship between SHYPO and poor sleep quality in a large Chinese population.
Keywords: subclinical hypothyroidism, sleep quality, PSQI