Abstract: Hydrogen sulfide (H₂S) is now increasingly considered to be the third gasotransmitter alongside other gaseous signaling molecules, nitric oxide (NO) and carbon monoxide (CO). H₂S is produced by a variety of endogenous enzymatic and non-enzymatic pathways and acts as a modulator of the physiological and pathological events of the body. Adipocytes express the cystathionine γ lyase (CSE)/H₂S system, which modulates a variety of biological activities in adipose tissue (AT), including inflammation, apoptosis, insulin resistance, adipokine secretion and adipocyte differentiation. Abnormalities in the physiological functions of AT play an important role in the process of diabetes mellitus. Therefore, this review provides an overview of the general aspects of H₂S biochemistry, the effect of H₂S on AT function and diabetes mellitus and its molecular signalling mechanisms as well as the potential application of H₂S in pharmacotherapy.
Keywords: hydrogen sulfide, adipose tissue, diabetes mellitus, drug therapy