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长链多不饱和脂肪酸及其代谢物在老年性黄斑变性中对炎症的调控作用
Authors Ren J , Ren A, Deng X, Huang Z, Jiang Z, Li Z, Gong Y
Received 1 November 2021
Accepted for publication 20 January 2022
Published 9 February 2022 Volume 2022:15 Pages 865—880
DOI https://doi.org/10.2147/JIR.S347231
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Ning Quan
摘要：老年性黄斑变性（Age-related macular degeneration，AMD）是一种致盲性眼病，其发病率随年龄增长而显著增加。AMD 的病因复杂，包括衰老、脂质代谢异常、慢性炎症和氧化应激等。长链多不饱和脂肪酸（long-chain polyunsaturated fatty acids，LCPUFA）对眼部结构和功能至关重要。本文就 LCPUFA 对 AMD 中炎症的调节作用进行综述。LCPUFA 与衰老，自噬和慢性炎症有关。LCPUFA 被各种酶代谢为促炎和抗炎代谢物，这些代谢物响应氧化应激刺激炎症，引起先天和获得性免疫反应。本综述还讨论了可能的临床应用，为 AMD 及其他年龄相关性疾病的防治提供了新的靶点。
Keywords: inflammation, long-chain polyunsaturated fatty acids, age-related macular degeneration