Objective: We investigate the relationship between the changes of serum 25-hydroxyvitamin D3 (25(OH)D3) and vasohibin-1 (VASH-1) and renal function injury in patients with type 2 diabetic nephropathy.
Methods: In this study, 143 patients with diabetic nephropathy (DN) were selected as DN group, and 80 patients with type 2 diabetes mellitus were selected as T2DM group. The serum 25 (OH) D3, VASH-1, blood glucose index, inflammation index and renal function index were compared between the two groups. According to the urinary microalbumin/creatinine ratio (UACR), the DN group was divided into microalbuminuria group (UACR range≥ 30.0mg/g and < 300.0mg/g) and macroalbuminuria group (UACR≥ 300.0mg/g) for stratified comparison. The correlation between 25-hydroxyvitamin D3, VASH-1 and inflammation index and renal function index was analyzed by simple linear correlation analysis.
Results: The level of 25 (OH) D3 in DN group was significantly lower than that in T2DM group (P< 0.05). The levels of VASH-1, CysC, BUN, Scr, 24h urine protein, serum CRP, TGF-β 1, TNF-α and IL-6 in DN group were higher than those in T2DM group (P< 0.05). The level of 25 (OH) D3 in DN patients with massive proteinuria was significantly lower than that in DN patients with microalbuminuria. The level of VASH-1 in DN patients with massive proteinuria was higher than that in DN patients with microalbuminuria (P< 0.05). There was a negative correlation between 25 (OH) D3 and CysC, BUN, Scr, 24h urine protein, CRP, TGF-β 1, TNF-α, IL-6 in patients with DN (P< 0.05). VASH-1 was positively correlated with Scr, 24h urinary protein, CRP, TGF-β 1, TNF-α and IL-6 in patients with DN (P< 0.05).
Conclusion: The level of serum 25 (OH) D3 in DN patients was considerably decreased, and the level of VASH-1 was increased, which was related to the degree of renal function injury and inflammatory response.
Keywords: 25 hydroxyvitamin D3, angiogenesis inhibitor protein 1, type 2 diabetes, diabetic nephropathy, renal function damage, inflammation indicators