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宏基因组下一代测序有助于男性患者流产衣原体肺炎的诊断:病例报告和文献复习
Authors Gong F, Chen Z, Chang J, Liu J, Wang X, Mo W, Tan M, Jiang T
Received 8 February 2023
Accepted for publication 23 May 2023
Published 2 June 2023 Volume 2023:16 Pages 3463—3468
DOI https://doi.org/10.2147/IDR.S407741
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Héctor M Mora-Montes
Background: Chlamydia abortus is generally considered as the main cause of ruminants abortion, but it rarely causes human infection resulting in abortion or pneumonia.
Case Presentation: We report a case of male patient with pneumonia caused by Chlamydia abortus . Results of next generation sequencing (NGS) in the bronchoalveolar lavage fluid (BALF) indicated Chlamydia abortus infection. The patient was treated with intravenous infusion of doxycycline. The clinical symptoms of this patient were ameliorated significantly, and all these improvement were indicated by laboratory parameters significantly. Shown as chest computed tomography (CT), most of the inflammation had been absorbed after doxycycline treatment.
Conclusion: Chlamydia abortus mainly infects ruminants and occasionally humans. NGS has its own advantages of rapidity, sensitivity and specificity in detecting Chlamydia abortus . Doxycycline exhibits a great therapeutic effect on pneumonia caused by Chlamydia abortus .
Keywords: Chlamydia abortus , pneumonia, human, metagenomic next-generation sequencing, case report