Purpose: Cardiometabolic index (CMI) has been suggested as innovative measures for assessing the cardiometabolic status. However, there is a lack of relevant studies on exploring the relationship between CMI and insulin resistance (IR). Consequently, this study aims to examine the relationship between CMI and IR in subjects with type 2 diabetes mellitus (T2DM).
Patients and Methods: A cross-sectional study was performed on 2493 patients with T2DM (including 1505 males and 988 females). IR was measured through the homeostatic model assessment of insulin resistance (HOMA-IR), which was defined as HOMI-IR≥ 2.69. The relationship between CMI and IR was evaluated with Spearman’s correlation, ROC analysis, multiple logistic regression, generalized smooth curve fitting and subgroup analysis.
Results: CMI was correlated with HOMA-IR in patients with T2DM (Spearman correlation coefficient = 0.391 in females and 0.346 in males, P< 0.001). Through the multiple logistic regression analysis, CMI was significantly correlated with IR (OR=1.30, 95% CI=1.15– 1.47 in males and OR=1.62, 95% CI=1.32– 1.99 in females). In addition, a non-linear correlation between CMI and IR risk was identified. The AUC of CMI (AUC = 0.702 for males and 0.733 for females, all p < 0.01) was the largest compared with traditional indexes of adiposity and blood lipids. According to the subgroup analysis, the two had a more significantly positive correlation in females, the elderly and subjects with HbA1c < 7%.
Conclusion: In patients with T2DM, elevated CMI is significantly correlated with IR, as a useful index of IR.

Keywords: high density lipoprotein cholesterol, cardiometabolic index, waist-to-height ratio, insulin resistance, type 2 diabetes mellitus