Xingyue Huang,* Yugang Hu,* Yao Zhang, Qing Zhou

Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, 430061, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Qing Zhou, Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, No. 99 of Zhangzhidong Road, Wuhan, 430061, People’s Republic of China, Tel +86027-88041911, Email qingzhou@whu.edu.cn

Objective: To establish a radiomics nomogram based on two-dimensional ultrasound for risk assessment of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
Methods: This study retrospectively collected two-dimensional ultrasound images and clinical data from 52 patients with T2DM who underwent renal biopsy in our hospital from January 2023 to August 2023. Based on the pathological results, all patients were categorized into two groups: DKD (n=33) and non-DKD (n=19). The radiomic features of the segmented kidney in ultrasound pictures were retrieved and selected to calculate each patient’s rad-score. A predictive nomogram based on rad-score and clinical features was then constructed and validated based on the calibration curve.
Results: The rad-score for all patients were computed based on five imaging characteristics extracted from the ultrasound images. The predictive nomogram was developed with the rad-score, diabetic retinopathy, duration of diabetes, and glycosylated hemoglobin. Moreover, This radiomics nomogram showed outstanding calibration capability, discrimination as well as therapeutic usefulness.
Conclusion: We constructed a nomogram based on two-dimensional ultrasound for DKD in T2DM patientsThe model has been proven to have good predictive performance, showing its potential in identifying DKD in T2DM patients and assisting in making appropriate early interventions.

Keywords: diabetic kidney disease, rad-score, two-dimensional ultrasound, machine learning, nomogram