Yang Sun,1,2 Bo-Wei Liu,2 Xin Zhang,2 Fu-Zai Yin2 

1Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People’s Republic of China

Correspondence: Fu-Zai Yin, Email yinfuzai62@163.com

Background: Apolipoprotein (Apo) may be associated with sarcopenia in elderly inpatients with type 2 diabetes mellitus (T2DM), but fewer studies are available. In this study, we explored the association of ApoA1, ApoB, and ApoB/ApoA1 with sarcopenia and compared the predictive role of Apo indicators for sarcopenia in an elderly T2DM.
Objective: To investigate the relationships between the Apo and sarcopenia in elderly inpatients with T2DM.
Methods: This study included 253 inpatients with T2DM (mean age of 70.11± 5.44 years, 32.8% male). The inpatients were divided into the sarcopenic group (n = 100) and non-sarcopenic group (n = 153). The associations among the Apo and sarcopenia were assessed using multivariate analyses.
Results: Inpatients in the sarcopenia group showed lower ApoA1 levels than those in the non-sarcopenia group (1.25± 0.21 vs 1.36± 0.20 g/L, P < 0.05) and showed higher ApoB/ApoA1 and ApoB levels than those in the non-sarcopenia group (0.82± 0.27 vs 0.69± 0.19 g/L, P < 0.05;1.00± 0.32 vs 0.93± 0.24 g/L, P < 0.05, respectively). After adjusting for age and BMI, the logistic regression model indicated that ApoA1 was a protective factor for elderly inpatients with T2DM sarcopenia.(OR =0.079,95% CI: 0.021~0.306, P < 0.05);ApoB and AopB/AopA1 were risk factors for elderly inpatients with T2DM sarcopenia.(OR =3.578,95% CI:1.318~9.715, P < 0.05;OR =16.440,95% CI:4.437~60.427, P < 0.05, respectively). AopB/AopA1 provided an AUC value of 0.765 in elderly men.(95% CI: 0.665~0.866, P< 0.05).
Conclusion: ApoA1, AopB, and AopB/AopA1 are associated with sarcopenia in elderly inpatients with T2DM, and AopB/AopA1 may be a potential predictor of sarcopenia in elderly men with T2DM.

Keywords: type 2 diabetes mellitus, sarcopenia, Apolipoprotein A1, Apolipoprotein B, Apolipoprotein B/A1