Shaojie Jia,1,2 Xin Liu,3 Hongyan Qu,3 Xiaojing Jia1,3 

1Stroke Center, Affiliated Hospital, Beihua University, Jilin, 132011, People’s Republic of China; 2Department of Orthopedics, Affiliated Hospital, Beihua University, Jilin, 132011, People’s Republic of China; 3Department of Neurology II, Affiliated Hospital, Beihua University, Jilin, 132011, People’s Republic of China

Correspondence: Xiaojing Jia, Stroke Center and Department of Neurology II, Affiliated Hospital, Beihua University, 12 Jiefang Middle Road, Jilin, People’s Republic of China, Tel +86-432-62166364, Email jiaxiaojing@beihua.edu.cn; zhonghua_bh@163.com

Background: Cerebral microbleeds (CMBs) are an important risk factor for stroke recurrence and prognosis. However, there is no consensus on the safety of antiplatelet therapy in patients with ischemic stroke and CMBs.
Objective: This study aimed to observe the effects of dual antiplatelet therapy with aspirin and clopidogrel on bleeding conversion in patients with different degrees of CMBs.
Materials and Methods: An observational retrospective study was conducted on 160 patients with acute mild ischemic stroke admitted to the Stroke Center, Affiliated Hospital of Beihua University between March 2021 and December 2022. Patients were divided into the CMBs and non-CMB groups. The CMB group was then divided into the low, medium and high-risk groups. In two groups, all patients were administered dual antiplatelet therapy (aspirin 100 mg and clopidogrel 75 mg orally once a day for 21 days according to the Chinese Stroke Guidelines of 2018), and no other anticoagulant or antiplatelet drugs were administered during the treatment period. Head CT, National Institutes of Health Stroke Scale(NIHSS) and modified Rankin Scale (mRS) score were re-checked, and the number of bleeding conversions was calculated at 21 days.
Results: Five patients in the CMB group had intracranial hemorrhage (5/116, 4.3%), while no intracranial hemorrhage was observed in the non-CMB group. There were no differences in the conversion rate of cerebral hemorrhage, NIHSS score, or mRS score between two groups after dual antiplatelet therapy (p> 0.05). The conversion rate of cerebral hemorrhage in the high-risk group was higher than that in the non-CMB group (p< 0.05), but the NIHSS and mRS score showed no difference between the high-risk and non-CMB groups (p> 0.05).
Conclusion: Dual antiplatelet therapy with aspirin and clopidogrel does not significantly increase the risk of bleeding transformation; however, it improves neurological recovery or long-term prognosis in patients with acute ischemic cerebral stroke complicated by low-risk and middle-risk CMBs.

Keywords: acute ischemic cerebral infarction, cerebral microbleeds, dual antiplatelet therapy