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同伴关系对青少年孤独感的影响：心理韧性和 OXTR 基因的作用
Authors Liu S, Zeng Z, Qi Q, Yang Q, Hu Y
Received 19 January 2024
Accepted for publication 5 June 2024
Published 22 June 2024 Volume 2024:17 Pages 2477—2489
DOI https://doi.org/10.2147/PRBM.S460393
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Mei-Chun Cheung
Shuangjin Liu, Zihao Zeng, Qi Qi, Qin Yang, Yiqiu Hu
School of Educational Science, Hunan Normal University, Changsha, 410006, People’s Republic of China
Correspondence: Yiqiu Hu, School of Educational Science, Hunan Normal University, Changsha, 410006, People’s Republic of China, Email fortune2000947@163.com
Background: Based on the gene-environment interaction paradigm, this study explored the effect of peer relationships on adolescent loneliness and the role of psychological resilience and the oxytocin receptor gene (OXTR).
Methods: A survey was conducted in a sample of 619 adolescents, and their oral cells were collected for DNA extraction and genotyping.
Results: The results showed that (1) both peer relationships and psychological resilience significantly affected adolescent loneliness; (2) psychological resilience partially mediated the relationship between peer relationships and loneliness in adolescents; (3) OXTR gene rs53576 polymorphism moderated both the first and second half of the indirect pathway of the mediation model. Specifically, carriers of the rs53576 polymorphism A/A genotype showed a significantly enhanced effect of peer relationships on adolescent psychological resilience, while carriers of the rs53576 polymorphism G/G genotype showed a significantly enhanced effect of psychological resilience on adolescent loneliness.
Conclusion: These findings helped elucidate the developmental mechanisms of adolescent loneliness in terms of peer relationships, psychological resilience, and OXTR gene polymorphisms.
Plain Language Summary: A moderated mediation effects analysis was conducted to investigate the effect of peer relationships on adolescent loneliness and the role of psychological resilience and the oxytocin receptor gene (OXTR). The results revealed psychological resilience partially mediated the relationship between peer relationships and loneliness in adolescents; OXTR gene rs53576 polymorphism moderated both the first and second half of the indirect pathway of the mediation model. These findings helped elucidate the developmental mechanisms of adolescent loneliness in terms of peer relationships, psychological resilience, and OXTR gene polymorphisms.
Keywords: peer relationship, adolescents, loneliness, psychological resilience, OXTR gene