Jun Song,1 Ning Li,1 Ruihua Li,1 Yuanyuan Xu2 

1Department of Pediatrics, Taihe County People’s Hospital, Fuyang, Anhui, 236000, People’s Republic of China; 2Pediatric Intensive Care Unit, Anhui Children’s Hospital, Hefei, Anhui, 230051, People’s Republic of China

Correspondence: Yuanyuan Xu, Pediat Intens Care Unit, Anhui Children’s Hospital, 39 Wangjiang East Road, Baohe District, Hefei, Anhui, 230051, People’s Republic of China, Tel +86-551-62237451, Email Xuyuanyuan7451@163.com

Objective: This study aimed to probe the changes in coagulation function-related indicators (prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (D-D), and fibrinogen degradation product (FDP)) in severe pneumonia and their clinical significance.
Methods: The levels of coagulation function indicators of all the children were measured within 24 hours of admission. Pearson correlation analysis was utilized to analyze the correlation between PT, APTT, FIB, D-D, FDP and PCIS in children with severe pneumonia. The ROC curve was drawn to assess the power of PT, APTT, FIB, D-D and FDP in diagnosing severe pneumonia and predicting the prognosis of severe pneumonia. A logistic regression analysis was implemented to analyze the factors influencing the prognosis of children with severe pneumonia.
Results: PT, APTT, FIB, FDP, and D-D in the critically severe pneumonia and the extremely severe pneumonia groups were higher versus the common pneumonia group (P < 0.05). FDP and D-D levels in children with severe pneumonia were negatively correlated with PCIS. PT, APTT, FIB, FDP, and D-D of children in the poor prognosis group were higher compared with those in the good prognosis group (P < 0.05). Further logistic regression analysis unveiled that FDP and APTT were influential factors impacting the prognosis of severe pneumonia.
Conclusion: The levels of D-D, FDP, FIB, APTT, and PT in severe pneumonia are increased. Detecting the contents of coagulation function indicators can help clinical judgment of the changes in the condition of severe pneumonia and evaluate prognosis.

Keywords: severe pneumonia, prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, fibrinogen degradation product, pediatric critical illness score