Yuanyuan Li,1,* Shanting Yi,1,* Wencai Jiang,2,* Meihui Gong1 

1Cardiovascular Center of the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, People’s Republic of China; 2Department of Cardiology, Suining Central Hospital, Suining, 629000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Meihui Gong, Cardiovascular Center of the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, People’s Republic of China, Email yuxy69@mail.sysu.edu.cn

Background: Previous studies have established a strong association between obesity, high metabolism, and the development of hyperuricemia. However, the relationship between obesity metabolism indices and hyperuricemia in high-risk patients with hypertension and coronary heart disease (CHD) remains unclear. The purpose of this study was to investigate this relationship in patients with both hypertension and CHD, and to identify the obesity metabolism index with the best diagnostic value.
Methods: A two-center study encompassed 6344 participants with hypertension and CHD. Multiple logistic regression was utilized to examine the correlation between six obesity metabolism indices and hyperuricemia, with restricted cubic spline (RCS) analysis to identify non-linear relationships. Diagnostic value was assessed via receiver operating characteristic (ROC) curves and decision curve analysis (DCA).
Results: Multivariable logistic regression revealed a significant correlation between increased obesity metabolism indices and hyperuricemia. Furthermore, RCS analysis revealed a nonlinear dose-response relationship (P for nonlinear < 0.001). Moreover, ROC and DCA results showed that METS-VF index, which combined visceral obesity and metabolic parameters, became the most reliable diagnostic tool.
Conclusion: The study underscores a strong association between elevated obesity metabolism indices and hyperuricemia in patients with hypertension and CHD. The METS-VF index, amalgamating visceral obesity and metabolic parameters, emerged as the most reliable diagnostic tool.

Keywords: obesity metabolism indices, hypertension, coronary heart disease, uric acid, hyperuricemia